Endocrine Abstracts

Introduction: C-peptide is frequently used in clinical practice to estimate insulin secretion, and guide need for future insulin treatment. Present practice is based on studies with small patient numbers.Aim: To explore the association between non-stimulated c-peptide and progression to insulin therapy in patients with diabetes.Patients and Methods: 1971 patients with c-peptide measurements were identified (February 2007–Decem...

Background: C-peptide consists of 31 amino acids, synthesized in the beta cells of the pancreas and co-secreted along with insulin. Hence, serum C-peptide may be the preferred diagnostic biomarker for evaluating beta cell function compared to insulin. The urinary C-peptide to creatinine ratio (UCPCR) recently gained attention as a non-invasive biomarker for evaluating and monitoring metabolic risk. In this study, we aimed to characterize guiding values of UCPCR in healthy indi...

Introduction: Recently, it was suggested that insulin resistance index using C-peptide (CIR) could be a better marker of insulin resistance than homeostasis model assessment (HOMA-IR) in patients with type 2 diabetes mellitus. The aim of this study was to investigate performance of CIR index in PCOS subjects.Methods: We evaluated 187 PCOS women (PCOS: 25.38±6.32 kg/m2; 26.01±5.16 years) diagnosed using ESHRE/ASRM criteria and 42 heal...

Introduction: Decrease in thyroid hormones (TH) levels is associated with reduced blood flow to kidneys and decreased glomerular filtration rate (GFR) along with alteration of tubular reabsorption.Deiodinase type 1 is an enzyme that is active in liver and kidneys and plays an important role in TH metabolism.The aim of the research was to study the dependence of markers of renal function on C/T polymorphism in the DIO 1 gene in pati...

Introduction: A standard oral glucose tolerance test (OGTT) measures samples at 0, 30, 60, 90, 120 min. Insulin and c-peptide are taken along with blood glucose (BG). Whether samples between baseline and 120 min provide any additional value in detecting children at high risk in clinical practice is not well documented. This audit is looking at the value of doing insulin and c-peptide within 2 h post glucose ingestion in otherwise healthy children seen in Oxford Children’s...

BackgroundMedical nutrition therapy is often the initial step in the management of Prediabetes and diabetes mellitus. Postprandial glycaemia contributes significantly to the glycaemic control of patients with diabetes mellitus. The beneficial effects of soluble dietary fibre in reducing postprandial glycaemia have been established. The 2017 global burden of disease (GBD) report shows that 97.000 deaths result from low fibre intake. Despite the this, the ...

Objective: Cystatin C has been proposed as a novel marker of renal function and as a predictor of the severity of coronary atherosclerosis and future cardiovascular events. The aim was to evaluate the possible role of chronic kidney disease and particularly CysC on the characteristics of carotid atherosclerosis in patients with type 2 diabetes (DT2).Materials and methods: We investigated 195 patients both sexes with DT2 aged 56.54±4.17 years. Contro...

We report on a patient whose type 2 diabetes resolved following interferon-α (IFN-α) therapy for hepatitis C virus (HCV). A 57-years-old man, presented with fatigue, polyuria and polydipsia. He was newly diagnosed with type 2 diabetes. During the hospital day, he was also diagnosed with chronic hepatitis. Serological studies for chronic hepatitis demonstrated presence of hepatitis C, type 2a/2c genotype. He was started on subcutaneous insulin and IFN-α. After 24...

Background: We have previously demonstrated colonic expression of the endogenous GH secretagogue, ghrelin, but not the GHS-R, and that ghrelin exerts proliferative effects on colonic epithelial cells. However, whether these are specific to ghrelin, or which genes are affected in response is uncertain.Aims: Determine the specificity of the proliferative effects of ghrelin on colonic epithelial cells, and effects on mRNA levels of the cancer associated ge...

Background and aims: To assess the prevalence and variability of pathogenic or likely pathogenic autosomal dominant mutations (ADM) of Familial Hypercholesterolemia (FH) in a Finnish cohort of patients with premature coronary artery disease (CAD) and elevated LDL-C levels.Methods: Study population was enrolled from 162 patients diagnosed with premature CAD (men < 55 years and women < 60 years) and history of high LDL-C (≥ 5 mmol/l) levels, ...